Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior

Two genome duplications early in the vertebrate lineage expanded gene families, including GluN2 subunits of the NMDA receptor. Diversification between the four mammalian GluN2 proteins occurred primarily at their intracellular C−terminal domains (CTDs). To identify shared ancestral functions and diversified subunit−specific functions, we exchanged the exons encoding the GluN2A (also known as Grin2a) and GluN2B (also known as Grin2b) CTDs in two knock−in mice and analyzed the mice's biochemistry, synaptic physiology, and multiple learned and innate behaviors. The eight behaviors were genetically separated into four groups, including one group comprising three types of learning linked to conserved GluN2A/B regions. In contrast, the remaining five behaviors exhibited subunit−specific regulation. GluN2A/B CTD diversification conferred differential binding to cytoplasmic MAGUK proteins and differential forms of long−term potentiation. These data indicate that vertebrate behavior and synaptic signaling acquired increased complexity from the duplication and diversification of ancestral GluN2 gene

Belonging in Higher Education

Vikki Hill - ORCID: 0000-0002-9277-2715 https://orcid.org/0000-0002-9277-2715Item is not available in this repository.In this episode of Interrogating Spaces we explore the value of belonging in Higher Education. Compiling together interviews with education professionals from across the globe as well as staff and students from UAL, we get a rounded picture of key concepts and issues at play. Through these discussions, we establish the barriers and conditions of belonging and how staff can build greater communities of belonging with their students.https://interrogatingspaces.buzzsprout.com/683798/4671476-belonging-in-higher-educationpubpu

Belonging in Online Learning Environments

Vikki Hill - ORCID: 0000-0002-9277-2715 https://orcid.org/0000-0002-9277-2715Item is not available in this repository.Following on from the previous of interrogating spaces that explored concepts of belonging in Higher Education, we move to online learning environments. In the context of Covid-19 and the sharp move to online teaching across the globe, we hear practitioners, academics and students reflect on how we can foster and develop a sense of belonging in digital spaces. We hear about the challenges and affordances of online environments, as well as suggestions as to how we might create a sense of presence and help student feel valued.https://interrogatingspaces.buzzsprout.com/683798/4795271-belonging-in-online-learning-environmentspubpu

The best American short stories 2001

A wonderfully diverse collection, this year's Best American Short Stories travels from Hollywood to Hong Kong, from the Jersey shore to Wales, considering the biggest issues: love, war, health, success.xix, 378 p.; 21 c

Al-Tabaqat al-Kubra

A wonderfully diverse collection, this year's Best American Short Stories travels from Hollywood to Hong Kong, from the Jersey shore to Wales, considering the biggest issues: love, war, health, success.xix, 378 p.; 21 c